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Fifty-nine (79%) patients had a diabetes diagnosis

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Deregulated activation of c-Met contributes to a few aspects of tumor progression, such as inducing neoplastic cells to disaggregate from the tumor mass, eroding basement membranes, infiltrating stromal matrices, and finally colonizing new tissues to form metastases ( Onset Chronic liver diseases such as cirrhosis and hepatitis B or C are triggers of HCC (Janevska et al., 2015)

However, it remains uncertain whether these observations reflect direct modulation of aging-related mitochondrial decline or secondary improvements resulting from restored metabolic homeostasis